Cat.No.

CADF054

Product Name

Quillaja saponaria (>95%, EU GMP grade, Vaccine adjuvant)

Subclassification

Adjuvants for protein-based vaccines

Classification

Adjuvant

Storage

Supplied as powder or in PBS, pH 7.4 (5 mg/ml or or see lot sp. conc on the vial. Store solution at -20°C. Reconstitute powder in
water and sterile filter if necessary.
Storage and Stability: Shipped at room temperature if powder and in cold paks for solution. Stored at -20°C. Long term storage at -20°C for up to 6 months. Avoid repeated freeze thaw cycles.

Recommended Usage

Mice: 10-20 ug
G. pigs/Rat: 25-50 ug
Rabbits/Monkey: 50-100 ug.
Notes: The adjucvant does is also dictated by the nature of antigen so it is possible to test different doses.

Description

QS-21 is a purified plant extract that enhances the ability of the immune system to respond to vaccine antigens. It is derived
from the Soap bark tree (Quillaja saponaria), which is native to the country of Chile. The extract contains water soluble triterpene glucoside compounds, which are members of a family of plant-based compounds called saponins. QS-21 Stimulon activates key components of the immune system including cellular (T cell mediated) and humoral (antibody mediated) immunity. Both of these components of the immune system are often necessary to enable the body to heal or protect itself. Stimlon has been studied in over 120 clinical trials involving approximately 50,000 patients during nearly 15 years of development. QS-21 Stimulon is currently a key adjuvant component in 20 clinical development programs of Agenus, GSK and J&J.